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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: Previous studies have indicated that miRNAs are important for hair follicle development and growth.In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool folliclebulbs in anagen phase compared with the telogen phase of the hair follicle cycle.could activate the Wnt/β-catenin signal pathway by targeting to promote the proliferation of human hairfollicle cells.

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract:

Sensory hair cells in the inner ear are responsible for sound recognition.Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannotBoth signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochleaIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationcell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract:

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animalsSince Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells afterefforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hairFurthermore, this review highlights the current limitations of hair cell regeneration and provides thepossible solutions to regenerate functional hair cells and to partially restore vestibular function.

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract:

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

Keywords： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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Relationship between selenium concentration in child hair and the distribution of Kashin-Beck Disease

LI Shunjiang, YANG Linsheng, WANG Wuyi, LI Yonghua, LI Hairong, XIRAO Ruodeng

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 223-225 doi: 10.1007/s11684-007-0043-1

Abstract: focus of this study is to determine the relationship between selenium (Se) concentrations in child hairThe hair of children in typical KBD-affected areas and non-disease areas was collected, and its Se concentrationsThe Se concentrations in child hair were (0.13±0.04) and (0.18±0.07) µg/g respectively in KBD areas andIn areas supplemented with Se in Tibet, the Se concentration of hair in KBD- affected areas was higherThere is a close relationship between the Se concentrations in hair and KBD distribution.

Keywords： different     relationship     non-disease     selenium     KBD distribution    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear hairResults showed that apigenin significantly ameliorated the loss of hair cells and the accumulation ofabolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hairThis study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: Herein, the extra biological functions of pituitary hormones, thyroid-stimulating hormone, follicle-stimulating

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:  CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear hairstereociliary bundles and the migration of kinocilia are critical indicators of planar cell polarity (PCP) of hairLKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity duringOur results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 236-252 doi: 10.15302/J-FASE-2018223

Abstract: that okra shaped leaves reduced adult whitefly oviposition preference, while glabrous leaves and high hair

Keywords： Bemisia tabaci     Gossypium genotypes     gossypol     leaf hair density     leaf hair length    

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Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 250-257 doi: 10.1007/s11684-016-0454-y

Abstract: inner-ear-specific alternative splicing, and as a result, Cdh23(+68) is only expressed in inner ear hair

Keywords： alternative splicing     inner ear     hearing loss     hair cells    

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is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 690-704 doi: 10.1007/s11684-018-0638-8

Abstract: encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia inWe observed significant hearing loss and progressive degeneration of stereocilia in the outer hair cells

Keywords： TPRN     stereocilia     stereociliary rootlet     actin filament     CRISPR/Cas9     hearing    

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: Treatment of small yellow follicles with follicle-stimulating hormone and estradiol resulted in a markedhead-to-head genes of and exhibit similar expression in chicken follicles and are involved in chicken follicle

Keywords： chicken     Vps36     Ckap2     mRNA     follicle    

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Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 16-20

Abstract:

The combined oral contraceptives (COCs) are combinations of exogenous estrogen and progestin. The primary mode of action for COCs is thought to be suppression of the pituitary-ovarian axis by higher than physiological levels of estrogen and progestin, secondarily leading to suppression of endogenous gonadotropin and gonadal hormone secretion and ovarian function. During the hormone-free interval (HFI), COCs users experience activation of their pituitary–ovarian axis. The level of hormones and follicular development are associated with the doses of estrogen, progestin formulations and the changes of HFI.

Keywords： COCs     HFI     hormone     follicle    

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Ovulation detection by transvaginal ultrasound and ovulation induction for two types of ovulation disorder

Liu Li,Wu Chunlin,Hu Yajun

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 31-35

Abstract: characteristics from patients with normal ovulation，small follicular ovulation and luteinized unruptured follicleRetrospective analyzing the difference of the patients’age，basal serum gonadal steroid hormones and folliclein the groups of normal ovulation（n=258）， small follicular ovulation（n=65）and luteinized unruptured folliclewas carried out in the 58 cases of small follicles ovulation and 25 cases of luteinizing unruptured follicleIncidence rates of small follicular ovulation and luteinized unruptured follicle were 18.5 % and 7.71

Keywords： transvaginalultrasound     ovulation detection     small follicular ovulation     luteinized unruptured follicle    

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Title Author Date Type Operation

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article

Relationship between selenium concentration in child hair and the distribution of Kashin-Beck Disease

LI Shunjiang, YANG Linsheng, WANG Wuyi, LI Yonghua, LI Hairong, XIRAO Ruodeng

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Journal Article

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Journal Article

is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Journal Article

Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Journal Article

Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Huang Pei,Huang Xunbin

Journal Article

Ovulation detection by transvaginal ultrasound and ovulation induction for two types of ovulation disorder

Liu Li,Wu Chunlin,Hu Yajun

Journal Article